NOVEL CRYSTALLINE HYDRATE, AMORPHOUS AND POLYMORPHIC FORMS OF DIHYDRO-BENZOXAZOLE-6-YL-ACETAMIDE DERIVATIVE AND PROCESSES FOR THEIR PREPARATION

The invention relates to novel crystalline hydrate, amorphous and crystalline polymorphic forms of 2-[4-(4-Fluoro-benzyl)-piperidine-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro- benzoxazole-6-yl)-acetamide (I) (radiprodil). Processes for the preparation of these forms, compositions containing these forms, and...

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Main Authors NEMET, ZOLTAN, SEBOK, FERENC, DEMETER, ADAM, BARTANE, SZALAI, GIZELLA, NEMES, ANDRAS, CZIBULA, LASZL?
Format Patent
LanguageEnglish
French
Published 21.07.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to novel crystalline hydrate, amorphous and crystalline polymorphic forms of 2-[4-(4-Fluoro-benzyl)-piperidine-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro- benzoxazole-6-yl)-acetamide (I) (radiprodil). Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described. L'invention porte sur de nouvelles formes cristallines amorphes hydratées et cristallines polymorphes du 2-[4-(4-fluorobenzyl)-pipéridine-1-yl]-2-oxo-N-(2-oxo-2,3-dihydrobenzoxazol-6-yl)-acétamide (I) (radiprodil). L'invention porte également sur des procédés de préparation de ces formes, sur des compositions contenant ces formes et sur des procédés d'utilisation de celles-ci.
Bibliography:Application Number: WO2010HU00023