HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula A-R wherein A is a hetereoaryl and R is Ia, Ib or Ic and wherein A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, Ra, Rb, Rc, Rd, X, X1, X2 and n are as are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for...

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Bibliographic Details
Main Authors ABBOT, SARAH C, TALAMAS, FRANCISCO XAVIER, LUI, ALFRED SUI-TING, LI, JIM
Format Patent
LanguageEnglish
French
Published 10.09.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds having the formula A-R wherein A is a hetereoaryl and R is Ia, Ib or Ic and wherein A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, Ra, Rb, Rc, Rd, X, X1, X2 and n are as are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication. L'invention porte sur des composés représentés par la formule A-R, dans laquelle A représente un hétéroaryle et R représente Ia, Ib ou Ic et dans laquelle A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, Ra, Rb, Rc, Rd, X, X1, X2 et n sont tels que définis dans la description. Lesdits composés sont des inhibiteurs de la polymérase NS5b du virus de l'hépatite C. L'invention porte également sur des compositions et des procédés de traitement d'une infection à VHC et d'inhibition de la réplication du VHC.
Bibliography:Application Number: WO2010EP52661