PEPTIDES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND USES THEREOF

Use of an isolated peptide comprising an amino acid sequence being no more than 25 amino acids in length, the amino acid sequence comprising at least one aspartate or a homolog thereof, the peptide having an Insulin-Degrading Enzyme (IDE) inhibitory activity, for the manufacture of a medicament iden...

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Bibliographic Details
Main Authors FRENKEL, DAN, LIFSHITZ, VERONICA, BORENSTEIN, NOFIT, BENROMANO, TALI, KOPELEVICH, ADI
Format Patent
LanguageEnglish
French
Published 16.12.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Use of an isolated peptide comprising an amino acid sequence being no more than 25 amino acids in length, the amino acid sequence comprising at least one aspartate or a homolog thereof, the peptide having an Insulin-Degrading Enzyme (IDE) inhibitory activity, for the manufacture of a medicament identified for treating a disease selected from the group consisting of diabetes, obesity, hyperglycemia, retinal damage, renal failure, nerve damage, microvascular damage and varicella-zoster virus (VZV) infection is disclosed. La présente invention concerne l'utilisation d'un peptide isolé comprenant une séquence de pas plus de 25 acides aminés, ladite séquence d'acides aminés comprenant au moins un aspartate ou un homologue de celui-ci et ledit peptide présentant une activité inhibitrice sur l'insulysine (IDE), en vue de la fabrication d'un médicament identifié pour sa capacité à traiter une maladie choisie dans le groupe constitué du diabète, de l'obésité, de l'hyperglycémie, des lésions rétiniennes, des insuffisances rénales, des lésions nerveuses, des lésions microvasculaires et des infections à virus varicelle-zona (VZV).
Bibliography:Application Number: WO2010IL00093