CRYSTALLINE POLYMORPHIC FORMS OF AN ANTIDIABETIC COMPOUND

• Main Authors: BAXTER, JENNIFER, VAYNSHTEYN, YEKATERINA, SCOTT, JEREMY, CHUNG, JOHN, Y., L, COTE, AARON, S, ARTINO, LAURA, ZHANG, YANFENG, DESMOND, DONAL
• Format: Patent
• Language: English; French
• Published: 15.07.2010
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention relates to polymorphic forms of a compound of formula A: This compound is useful as a glucagon receptor antagonist and serves as a pharmaceutically active ingredient for the treatment of type 2 diabetes and related conditions, such as hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. Hydrates, hemihydrates, anhydrates and similar polymorphic forms are included. La présente invention concerne des formes polymorphes d'un composé de la formule A : Ce composé est utile en tant qu'antagoniste du récepteur du glucagon et sert de principe pharmaceutique actif pour le traitement du diabète non insulinodépendant et des pathologies associées, telles que l'hyperglycémie, l'obésité, la dyslipidémie et le syndrome métabolique. L'invention concerne également des hydrates, des semi-hydrates, des anhydrates et des formes polymorphes semblables.