CRYSTALS OF HYDROCHLORIDE OF PYRIDAZIN-3(2H)-ONE COMPOUND AND PROCESS FOR PRODUCTION OF SAME

• Main Authors: NISHITANI, JUNICHI, KAWAHARA, SHIRO
• Format: Patent
• Language: English; French; Japanese
• Published: 01.07.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are novel crystals of 4-bromo-6-(3-(4-chloro- phenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one monohydrochloride, and a process for production of same. A-form crystals of 4-bromo-6-(3-(4-chlorophenyl)propoxy) -5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one monohydro- chloride represented by formula (1), which exhibit a powder X-ray diffraction pattern with characteristic peaks at diffraction angles (2?) of 8.24, 11.24, 11.76, 16.48, 17.16, 17.80, 18.24, 19.80, 21.64, 22.56, 22.96, 23.68, 24.52, 25.92, 26.32, 27.12, 27.40, 28.00, 28.64, 29.28, 31.84, and 34.80°. L'invention porte sur de nouveaux cristaux de monochlorhydrate de 4-bromo-6-(3-(4-chloro-phényl)propoxy)-5-(pyridin-3-ylméthylamino) pyridazin-3(2H)-one et sur leur procédé de fabrication. Les cristaux de forme A de monochlorhydrate de 4-bromo-6-(3-(4-chloro- phényl)propoxy)-5-(pyridin-3-ylméthylamino)pyridazin-3(2H)-one représentés par la formule (1) présentent un diagramme de diffraction des rayons X sur poudre avec des pics caractéristiques à des angles de diffraction de (2?) de 8,24, 11,24, 11,76, 16,48, 17,16, 17,80, 18,24, 19,80, 21,64, 22,56, 22,96, 23,68, 24,52, 25,92, 26,32, 27,12, 27,40, 28,00, 28,64, 29,28, 31,84 et 34,80°.