FLUORESCENT PROBES

• Main Author: TOLLESHAUG, HELGE
• Format: Patent
• Language: English; French
• Published: 01.07.2010
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present invention relates to quenched fluorescent probes which arc activated by biochemical processes. The probes are designed such that intramolecular quenching occurs in the unactivated probe, but that the quencher moieties are cleaved from the probe under defined conditions rendering the probe fluorescent. Also disclosed are optical imaging agents suitable for in vivo imaging comprising the probes, as well as pharmaceutical compositions and kits, as well as in vivo imaging methods. La présente invention concerne des sondes fluorescentes stoppées activées par des processus biochimiques. Les sondes sont conçues de sorte à ce que le stoppage intramoléculaire se produise dans la sonde inactivée, mais que les groupements stoppeurs soient clivés de la sonde dans des conditions définies qui permettent d'obtenir leur fluorescence. La présente invention concerne également des agents d'imagerie optique adaptés à l'imagerie in vivo incluant lesdites sondes, ainsi que des compositions pharmaceutiques et des kits, et des méthodes d'imagerie in vivo.