THIENO [3, 2-C] PYRIDINE DERIVATIVES AS KINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER

Compounds that inhibit protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved safety profile due to low CYP3A4 inhibition, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. La présente invention por...

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Bibliographic Details
Main Author MICHAELIDES, MICHAEL, R
Format Patent
LanguageEnglish
French
Published 26.08.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds that inhibit protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved safety profile due to low CYP3A4 inhibition, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. La présente invention porte sur des composés qui inhibent des protéines kinases telles que des Aurora-kinases et les familles VEGFR et PDGFR de kinases, dont le profil d'innocuité est amélioré en raison d'une inhibition faible de CYP3A4, sur des compositions contenant les composés et sur des méthodes de traitement de maladies à l'aide des composés.
Bibliography:Application Number: WO2009US66725