PHARMACEUTICAL COMPOSITIONS COMPRISING DEFERASIROX

• Main Authors: JAIN, SATISHKUMAR, PANANCHUKUNNATH, MANOJ, KUMAR, LADANI, NIKUNJ, SWAMINATHAN, BOOPALAN, BHUSHAN, INDU, SINGH, UDAY, KUMAR, MENDIRATTA, AJAY, K, GUPTA, RAJESH
• Format: Patent
• Language: English; French
• Published: 01.04.2010
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The invention relates to oral pharmaceutical composition comprising deferasirox or pharmaceutically acceptable salts, polymorphic forms and mixtures thereof, wherein the active ingredient has a mean particle size less than about 100µm and is present in an amount greater than 66% by weight based on total weight of the tablet. The invention also relates to process for preparing said oral pharmaceutical compositions and its uses thereof. L'invention concerne une composition pharmaceutique orale comprenant du déférasirox ou des sels pharmaceutiquement acceptables, des formules polymorphes et des mélanges de ceux-ci. L'ingrédient actif a une granulométrie moyenne inférieure à environ 100 Êm et est présent en dose  supérieure à 66% en poids sur la base du poids total du comprimé. L'invention concerne également un procédé de préparation desdites compositions pharmaceutiques orales et à leurs utilisations associées.