2-AMINO PYRIMIDINE COMPOUNDS AS POTENT HSP-90 INHIBITORS

The present invention is directed to compounds of Formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors in the treatment of proliferative diseases, e.g. cancer. La présente invention concerne les composés de formule (I), ou des sels pharmaceut...

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Bibliographic Details
Main Authors KUNG, PEI-PEI, MENG, JERRY JIALUN
Format Patent
LanguageEnglish
French
Published 18.02.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to compounds of Formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors in the treatment of proliferative diseases, e.g. cancer. La présente invention concerne les composés de formule (I), ou des sels pharmaceutiquement acceptables de ceux-ci, leur synthèse et leur utilisation comme inhibiteurs de l'HSP-90 dans le traitement de maladies prolifératives, par exemple le cancer.
Bibliography:Application Number: WO2009IB53277