ERYTHROPOIETIN RECEPTOR ANTIBODY AND USES THEREOF

The present invention relates to an antibody specific for a particular epitope of the erythropoietin receptor, or fragment or variant thereof. The antibody is defined by sequence and epitope to which it binds. The antibody or fragment thereof is capable of attenuating invasion of cancer cells. The i...

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Bibliographic Details
Main Authors OLWILL, SHANE, JAQUIN, THOMAS, JOHNSTON, JAMES, BURDEN, ROBERTA, BUICK, RICHARD J, MCCLURG, ANGELA
Format Patent
LanguageEnglish
French
Published 07.01.2010
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to an antibody specific for a particular epitope of the erythropoietin receptor, or fragment or variant thereof. The antibody is defined by sequence and epitope to which it binds. The antibody or fragment thereof is capable of attenuating invasion of cancer cells. The invention also relates to pharmaceutical composition comprising the antibody, and methods and uses of the antibody, including methods of treating proliferative disorders and anaemia. La présente invention concerne un anticorps spécifique d'un épitope particulier du récepteur d'érythropoïétine ou un de ses fragments ou variants. L'anticorps est défini par une séquence et l'épitope auquel il se lie. L'anticorps ou l'un de ses fragments est capable d'atténuer l'invasion de cellules cancéreuses. L'invention concerne également une composition pharmaceutique comprenant l'anticorps, et des procédés et des utilisations de l'anticorps, notamment des procédés de traitement d'affections prolifératives et de l'anémie.
Bibliography:Application Number: WO2009EP58535