STANDARDIZED EXTRACT AND FRACTION FROM HANCORNIA SPECIOSA LEAVES AND PHARMACEUTICAL COMPOSITION THEREOF

• Main Authors: DE FRANCA CORTES, STEYNER, COUTINHO ENDRINGER, DENISE, CASTRO BRAGA, FERNAO, CAROLINE DA SILVA, GRAZIELLE
• Format: Patent
• Language: English; French; Portuguese
• Published: 26.11.2009
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention describes a standardized extract obtained from the leaves of Hancornia speciosa Gomes (EHS), popularly known as "mangaba" in Brazil, as well as a standardized fraction with inhibiting activity on the angiotensin converting enzyme (ACE), and vasodilating, anti-hypertensive and antioxidant properties. The invention further relates to the preparation of pharmaceutical compositions that contain said extract or fractions derived from the extract of Hancornia speciosa Gomes leaves rich in cyclitols and flavonoids, as well as the use of same for the treatment of cardiovascular diseases such as arterial hypertension, atherosclerosis, stenosis, and non-limiting cardiac or cerebral ischaemia. La présente invention concerne l'obtention d'un extrait normalisé de feuilles de Hancornia speciosa Gomes (EHS), espèce vulgairement connue sous le nom de "mangaba", ainsi qu'une fraction normalisée présentant une activité inhibitrice de l'enzyme de conversion de l'angiotensine (ECA), une activité vasodilatatrice, une activité antihypertensive et une activité antioxydante. L'invention concerne également l'obtention de compositions pharmaceutiques contenant cet extrait ou des fractions dérivées de l'extrait de feuilles de l'espèce Hancornia speciosa Gomes riches en cyclitols et en flavonoïdes, ainsi que leur utilisation pour le traitement d'affections cardiovasculaires telles que l'hypertension artérielle, l'athérosclérose, la resténose ainsi que l'ischémie cardiaque ou cérébrale, entre autres. A presente invenção descreve a obtenção de um extrato padronizado de folhas de Hancomia speciosa Gomes (EHS), vulgarmente denominada "mangaba", e de uma fração padronizada com atividades inibidora da enzima conversora de angiotensina (ECA), vasodilatadora, anti-hipertensiva e antioxidante. A invenção compreende, ainda, a obtenção composições farmacêuticas que contem o extrato ou frações derivadas do extrato de folhas da espécie Hancomia speciosa Gomes ricas em ciclit?is e flavon?ides, bem como sua utilização para o tratamento de dist?rbios cardiovasculares como hipertensão arterial, aterosclerose, restenose, isquemia cardiaca ou cerebral não limitantes.