AN IMPROVED PROCESS FOR THE PREPARATION OF SOLIFENACIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

The present invention relates to an improved process for the preparation of solifenacin compound of formula (1) and its succinate salt compound of formula (1a), comprising the condensation of (R)-3- quinuclidinol with (S)-ethyl- 1 -phenyl- 1,2,3,4-tetrahydro-2-isoquinoline carboxylate in presence of...

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Bibliographic Details
Main Authors VENKATESH, MUMMADI, SATYANARAYANA REDDY, MANNE, ESWARAIAH, SAJJA
Format Patent
LanguageEnglish
French
Published 19.11.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to an improved process for the preparation of solifenacin compound of formula (1) and its succinate salt compound of formula (1a), comprising the condensation of (R)-3- quinuclidinol with (S)-ethyl- 1 -phenyl- 1,2,3,4-tetrahydro-2-isoquinoline carboxylate in presence of a suitable hydroxide base in a suitable solvent. La présente invention porte sur un procédé perfectionné de fabrication de composé de solifénacine de formule (1) et de son composé sel de succinate de formule (1a). Le procédé consiste à condenser du (R)-3-quinuclidinol avec du carboxylate de (S)-éthyl-1-phényl-1,2,3,4-tétrahydro-2-isoquinoléine en présence d'une base de type hydroxyde appropriée dans un solvant approprié.
Bibliography:Application Number: WO2009IN00278