DOUBLE-STRANDED POLYETHYLENE GLYCOL MODIFIED GROWTH HORMONE, PREPARATION METHOD AND APPLICATION THEREOF

Provided are double-stranded polyethylene glycol mono-modified growth hormones and preparation methods thereof. The pegylated growth hormone has the higher biology activity and longer half-life and so on compared with non-modified growth hormone. The composition comprising the pegylated growth hormo...

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Main Authors SHEN, SHIYE, ZHANG, DEFANG, ZHANG, PING, LIN, HUIHUANG, ZHANG, LINZHONG, LU, QINGSONG, SUN, LI, LIAO, XIAOJIN, ZHOU, WEIDONG, YANG, LISHAN
Format Patent
LanguageChinese
English
French
Published 08.10.2009
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are double-stranded polyethylene glycol mono-modified growth hormones and preparation methods thereof. The pegylated growth hormone has the higher biology activity and longer half-life and so on compared with non-modified growth hormone. The composition comprising the pegylated growth hormone can be used for treating growth or development disorder like growth hormone deficiency, Turner's syndrome etc. L'invention porte sur des hormones de croissance mono-modifiées par polyéthylèneglycol double brin et sur leurs procédés de préparation. L'hormone de croissance pégylée a une activité biologique supérieure et une plus longue durée de vie, etc. par comparaison avec l'hormone de croissance non modifiée. La composition comprenant l'hormone de croissance pégylée peut être utilisée pour traiter un trouble de la croissance ou du développement comme une carence en hormone de croissance, le syndrome de Turner, etc.
Bibliography:Application Number: WO2008CN00674