ENDOPLASMIC RETICULUM TARGETING LIPOSOMES

Provided are compositions that include lipid particles, such as liposomes, that can fuse with the ER membrane of a cell. The lipid particles can also deliver a cargo, such as a therapeutic or an imaging agent, encapsulated inside the particles inside the ER lumen of the cell. The compositions can be...

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Bibliographic Details
Main Authors ZITZMANN, NICOLE, DWEK, RAYMOND, ALLEN, POLLOCK, STEPHANIE
Format Patent
LanguageEnglish
French
Published 11.03.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided are compositions that include lipid particles, such as liposomes, that can fuse with the ER membrane of a cell. The lipid particles can also deliver a cargo, such as a therapeutic or an imaging agent, encapsulated inside the particles inside the ER lumen of the cell. The compositions can be useful for treating and/or preventing diseases or conditions caused by or associated with a virus, such as viral infections, including HIV and HCV infections. La présente invention concerne des compositions qui comprennent des particules de lipides, telles que des liposomes, qui peuvent fusionner avec la membrane du réticulum endoplasmique (RE) d'une cellule. Les particules de lipides peuvent également délivrer une charge, telle qu'un agent thérapeutique ou d'imagerie, encapsulée à l'intérieur des particules à l'intérieur de la lumière du RE de la cellule. Les compositions peuvent être utiles pour traiter et/ou prévenir des maladies ou pathologies causées par ou associées à un virus, telles que des infections virales, comprenant les infections par le VIH ou le VHC.
Bibliography:Application Number: WO2009IB05547