PROCESS FOR PREPARATION OF TAZAROTENE

Disclosed herein is process for preparation of 6-[2-(4,4-dimethylthiochroman-6- yl)ethynyl]nicotinate known as Tazarotene of Formula (I) and its pharmaceutical acceptable salts, wherein said process comprises, reacting 4,4-dimethyl-6- acetylthiochroman with chlorinating reagent to get novel intermed...

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Bibliographic Details
Main Authors DESHMUKH SANDIP KACHARU, VYAS KETAN DHANSUKHLAL, PANANDIKAR ADITI MILIND, BHATT NIKUNJ, NAIR RANJEET
Format Patent
LanguageEnglish
French
Published 24.09.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed herein is process for preparation of 6-[2-(4,4-dimethylthiochroman-6- yl)ethynyl]nicotinate known as Tazarotene of Formula (I) and its pharmaceutical acceptable salts, wherein said process comprises, reacting 4,4-dimethyl-6- acetylthiochroman with chlorinating reagent to get novel intermediate compound 6- (l,l-dichloroethyl)-4,4-dimethylthiochroman followed by converting the compound 6- (l,l-dichloroethyl)-4,4-dimethylthiochroman to get Tazarotene. L'invention concerne un procédé de préparation de 6-[2-(4,4-diméthylthiochroman-6-yl)éthynyl]nicotinate, connu sous le nom de tazarotène, représenté par la formule I, et de ses sels pharmaceutiques acceptables, ledit procédé comprenant la mise en réaction du 4,4-diméthyl-6-acétylthiochromane avec un réactif de chloration pour obtenir un nouveau composé intermédiaire, le 6-(1,1-dichloroéthyl)-4,4-diméthylthiochromane, suivie par la conversion du composé 6-(1,1-dichloroéthyl)-4,4-diméthylthiochromane pour obtenir le tazarotène.
Bibliography:Application Number: WO2009IN00101