SYSTEMIC PURINE ADMINISTRATION:MODULATING AXONAL OUTGROWTH OF CENTRAL NERVOUS SYSTEM NEURONS

Methods for modulating the axonal outgrowth of central nervous system neurons are provided by means of internalized purine administration such as by intravenous, intraarterial, subcutaneous, intramuscular, intraperitoneal, and intrapleural administration. The methods are noted for stimulating the ax...

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Main Authors CUSACK, NOEL, JAMES, THORN, RICHARD, M, HURTT, MARK, R
Format Patent
LanguageEnglish
French
Published 11.09.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods for modulating the axonal outgrowth of central nervous system neurons are provided by means of internalized purine administration such as by intravenous, intraarterial, subcutaneous, intramuscular, intraperitoneal, and intrapleural administration. The methods are noted for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, traumatic brain injury, cerebral aneurism, spinal cord injury and the like). L'invention concerne des procédés permettant la modulation de l'excroissance axonale des neurones du système nerveux central, lesdits procédés comprenant l'administration de purine par voie interne, et notamment l'administration par voie intraveineuse, intra-artérielle, sous-cutanée, intra-péritonéale et intra-pleurale. Lesdits procédés sont rapportés comme servant à stimuler l'excroissance axonale des neurones du système nerveux central à la suite d'une lésion (par exemple, un accident vasculaire cérébral, une lésion cérébrale traumatique, un anévrisme cérébral, une lésion de la moelle épinière et des lésions du même type).
Bibliography:Application Number: WO2009US35289