MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE

• Main Authors: CAMPBELL, DAVID ALAN, WINN, DAVID T, BETANCORT, JUAN MANUEL, HEPPERLE, MICHAEL E
• Format: Patent
• Language: English; French
• Published: 20.08.2009
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPIRITS; SUGARS; VINEGAR; WINE

The invention provides compounds inhibitory to the Hepatitis C viral protease, compositions and combinations including the compounds, methods of treatment of conditions wherein inhibition of the Hepatitis C viral protease is medically indicated, and methods of treatment of a Hepatitis C viral infection in a human patient. L'invention concerne des composés inhibiteurs de la protéase virale de l'hépatite C, des compositions et des combinaisons comprenant les composés, des procédés de traitement d'états dans lesquels une inhibition de la protéase virale de l'hépatite C est indiquée médicalement, et des procédés de traitement d'une infection virale par l'hépatite C chez un patient humain.