AMOURPHOUS FORM OF THE ADAMANTYLAMINO-PLATINUM ( IV) COMPLEXLA-12

• Main Authors: FRANC, ALES, KROUTIL, ALES, SOVA, PETR
• Format: Patent
• Language: English; French
• Published: 17.12.2009
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to the amorphous form of the compound (OC-6-43)- bis(acetato)(1-tricyclo[3,3,1,13,7]decylamine)amminedichloroplatinum(IV), (also called LA-12), methods of preparation, isolation and identification thereof, pharmaceutical compositions containing the same, and the use of such amorphous form and compositions in the treatment of oncological deseases. La présente invention concerne la forme amorphe du composé LA-12, à savoir le (OC-6-43) -bis(acétato) (1-tricyclo[3,3,1,13,7] décylamine) aminodichloroplatine (IV), des procédés d'élaboration, d'isolation et d'identification correspondants, des compositions pharmaceutiques les contenant, et l'utilisation d'un tel polymorphe et de telles compositions pour le traitement de maladies oncologiques.