2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN

Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed. L'invention concerne d...

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Main Authors VASUDEVAN, ANIL, BAYBURT, EROL, K, DAANEN, JEROME, F, KYM, PHILIP R, VOIGHT, ERIC, KOENIG, JOHN R, SCHMIDT, ROBERT, G, GOMTSYAN, ARTHUR, R, PERNER, RICHARD J, KORT, MICHAEL E, DIDOMENICO, STANLEY, JR
Format Patent
LanguageEnglish
French
Published 30.04.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed. L'invention concerne des composés de formule (I) dans laquelle R1, R2, R4 et W, qui sont définis dans la description, sont des antagonistes de TRPV1 avec pénétration du système nerveux central. Des compositions comprenant de tels composés et des procédés de traitement des affections et des troubles utilisant de tels composés et compositions sont également révélés.
Bibliography:Application Number: WO2008US81229