NOVEL CYCLIC BORONATE INHIBITORS OF HCV REPLICATION

• Main Authors: LIAO, LIANG, WHITE, GEMMA VICTORIA, FAN, DAZHONG, ZHANG, YONG KANG, LI, QUN, LI, XIANFENG, SLATER, MARTIN JOHN, NI, ZHI-JIE, QIAN, XUELEI, LAZARIDES, LINOS, PLATTNER, JACOB, JARVEST, RICHARD LEWIS, MORDAUNT, JACQUELINE ELIZABETH, LIU, YANG
• Format: Patent
• Language: English; French
• Published: 09.04.2009
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula (I) or a salt thereof are provided; wherein R1, R2, R3, R4, R6, R8, R20, R30, Y, Z and n are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicaments for treating viral infection, especially HCV infection are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. L'invention concerne des composés de formule (I) ou un sel de ceux-ci ; dans laquelle R1, R2, R3, R4, R6, R8, R20, R30, Y, Z et n sont tels que définis dans la description. Des utilisations des composés comme médicaments, et dans la fabrication de médicaments pour le traitement d'une infection virale, en particulier une infection par le virus de l'hépatite C sont également décrites. L'invention comprend en outre des procédés de préparation de ces composés et formulations pharmaceutiques de ceux-ci.