PROCESS FOR THE SYNTHESIS OF CMHTP, A PALIPERIDONE INTERMEDIATE

The present invention provides a process for 3-(2-chloroethyl)-6,7,8,9- tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]- pyrimidin-4-one (CMHTP), and its conversion to paliperidone. L'invention porte sur un procédé permettant d'obtenir de la 3-(2-chloroéthyl)-6,7,8,9- tétrahydro-9-hydroxy-...

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Bibliographic Details
Main Authors INI, SANTIAGO, SHMUELY, YARON
Format Patent
LanguageEnglish
French
Published 09.04.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a process for 3-(2-chloroethyl)-6,7,8,9- tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]- pyrimidin-4-one (CMHTP), and its conversion to paliperidone. L'invention porte sur un procédé permettant d'obtenir de la 3-(2-chloroéthyl)-6,7,8,9- tétrahydro-9-hydroxy-2-méthyl-4H-pyrrido[1,2-a]- pyrimidin-4-one (CMHTP), et de la transformer en palipéridone.
Bibliography:Application Number: WO2008US11433