FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY AND METHOD FOR THEIR PREPARATION

The present invention provides analogs of FR901464, as well as a methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing. L'invention concer...

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Bibliographic Details
Main Authors ALBERT, BRIAN, J, SIVARAMAKRISHNAN, ANANTHAPADMANABHAN, KOIDE, KAZUNORI
Format Patent
LanguageEnglish
French
Published 12.03.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides analogs of FR901464, as well as a methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing. L'invention concerne des analogues de FR901464 ainsi qu'un procédé de préparation de FR901464 et d'analogues de ce composé. Ces composés présentent une activité anticancéreuse et constituent des candidats pour traiter des états pathologiques associés à un dysfonctionnement de l'épissage d'ARN.
Bibliography:Application Number: WO2007US19550