STABILIZATION OF NUCLEIC ACIDS ON SOLID SUPPORTS

The present invention provides methods, compositions, and kits for the storage and stabilization of biological molecules. The methods comprise applying Tris(2-carboxyethyl)phosphine (TCEP) to at least one biological molecule bound to a solid substrate and storing in an organic solvent. Preferably, t...

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Bibliographic Details
Main Authors NOVORADOVSKAYA, NATALIA, BASEHORE, LEE, SCOTT, BRAMAN, JEFFREY, C
Format Patent
LanguageEnglish
French
Published 05.03.2009
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides methods, compositions, and kits for the storage and stabilization of biological molecules. The methods comprise applying Tris(2-carboxyethyl)phosphine (TCEP) to at least one biological molecule bound to a solid substrate and storing in an organic solvent. Preferably, the biological molecules are nucleic acids. Compositions and kits for performing the process according to the invention are also provided. La présente invention porte sur des procédés, des compositions et des kits pour le stockage et la stabilisation de molécules biologiques. Les procédés comprennent l'application de Tris(2-carboxyéthyl)phosphine (TCEP) à au moins une molécule biologique liée à un substrat solide et le stockage dans un solvant organique. De préférence, les molécules biologiques sont des acides nucléiques. L'invention porte également sur des compositions et des kits pour effectuer le procédé.
Bibliography:Application Number: WO2008US73429