PIPERIDINE DERIVATIVE

A study is made on a compound having a selective inhibitory activity on 17ßHSD type-5, and it is confirmed that a [1-[(indol-2-yl)carbonyl]piperidyl]alkanol derivative has a potent selective inhibitory activity on 17ßHSD type-5. The compound can be used as a therapeutic and/or prophylactic agent for...

Full description

Saved in:
Bibliographic Details
Main Authors KAKEFUDA, AKIO, WATANABE, KAZUSHI, ENJO, KENTARO, YASUDA, MINORU, KAMIKAWA, AKIO, FURUTANI, TAKASHI
Format Patent
LanguageEnglish
French
Japanese
Published 05.03.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:A study is made on a compound having a selective inhibitory activity on 17ßHSD type-5, and it is confirmed that a [1-[(indol-2-yl)carbonyl]piperidyl]alkanol derivative has a potent selective inhibitory activity on 17ßHSD type-5. The compound can be used as a therapeutic and/or prophylactic agent for a disease associated with 17ßHSD type-5 (e.g., benign prostatic hyperplasia, prostate cancer), and has no adverse side effect caused by the decrease in testosterone level. L'invention concerne un dérivé de pipéridine, selon lequel une étude est faite sur un composé ayant une activité inhibitrice sélective sur le 17ßHSD type-5, et il est confirmé qu'un dérivé de [1-[(indol-2-yl)carbonyl]pipéridyl]alcanol a une activité inhibitrice sélective puissante sur 17ßHSD type-5. Le composé peut être utilisé comme agent thérapeutique et/ou prophylactique pour une maladie associée au 17ßHSD type-5 (par exemple, hyperplasie prostatique bénigne, cancer de la prostate) et n'a pas d'effet secondaire défavorable provoqué par la diminution du taux de testostérone.
Bibliography:Application Number: WO2008JP65429