NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM

• Main Authors: FELIX, LUCIANA DE ARAUJO, ROGERS, JR., JOHN FRANCIS, VERA, MATTHEW DOUGLAS, GREEN, DANIEL MICHAEL, MOLINARI, ALBERT JOHN, MEHLMANN, JOHN FRANCIS, PELLETIER, JEFFREY CLAUDE, MANN, CHARLES WILLIAM, LUNDQUIST IV, JOSEPH THEODORE, HAUZE, DIANE BARBARA
• Format: Patent
• Language: English; French
• Published: 26.02.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-[beta-symbol]-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog. L'invention concerne des analogues de naphtylpyrimidine, des procédés de préparation d'analogues de naphtylpyrimidine,, des compositions comprenant un analogue de naphtylpyrimidine et de procédés pour traiter des troubles liés au système de communication cellulaire Wnt-[bêta-symbole]-caténine canonique comprenant l'administration à un sujet qui en a besoin d'une quantité efficace d'un analogue de naphtylpyrimidine, naphtylpyrazine et naphtylpyridazine.