COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES

• Main Authors: WINTER, GERHARD, GOTTSCHALK, STEFAN, BORHANI, DAVID W, FRAUNHOFER, WOLFGANG
• Format: Patent
• Language: English; French
• Published: 12.02.2009
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions. La présente invention se rapporte à un procédé de cristallisation discontinu permettant de cristalliser l'anticorps et les fragments d'anticorps antihumain TNFalpha (hTNFalpha). Ce procédé permet la production dudit anticorps à l'échelle industrielle. L'invention concerne également un procédé de contrôle de la taille de cristaux d'anticorps, par exemple, de cristaux de fragments d'anticorps anti-hTNFalpha, les compositions contenant lesdits cristaux ainsi que les procédés d'utilisation des cristaux et des compositions.