NOVEL CRYSTALLINE FORM OF A DIHYDROCHLORIDE SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR

• Main Authors: ELLISON, MARTHA, E, WENSLOW, ROBERT, M, VARIANKAVAL, NARAYAN
• Format: Patent
• Language: English; French
• Published: 29.01.2009
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention relates to a novel crystalline form of the dihydrochloride salt of (2R,3S,5S)-2-(2,5-difluorophenyl)-5-(4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)tetrahydro-2H-pyran-3-amine as well as a process for its preparation, pharmaceutical compositions containing this novel form, and methods of use of the novel form and pharmaceutical compositions for the treatment of Type 2 diabetes, hyperglycemia, insulin resistance, obesity, and high blood pressure. La présente invention porte sur une nouvelle forme cristalline du sel de dichlorhydrate de (2R,3S,5S)-2-(2,5-difluorophényl)-5-(4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)tétrahydro-2H-pyran-3-amine, ainsi que sur un procédé pour sa préparation, sur des compositions pharmaceutiques contenant cette nouvelle forme et sur des procédés d'utilisation de la nouvelle forme et des compositions pharmaceutiques pour le traitement du diabète de type 2, de l'hyperglycémie, de la résistance à l'insuline, de l'obésité et de l'hypertension.