MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS

A class of macrocyclic compounds of formula (I), wherein R7,A,Ar, B,D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Alsoprovided are processes for the synthesis and use of such m...

Full description

Saved in:
Bibliographic Details
Main Authors MACKAY, ANGELA CLAIRE, STANSFIELD, IAN, RICO FERREIRA, MARIA DEL ROSARIO, CONTE, IMMACOLATA, HABERMANN, JOERG, NARJES, FRANK
Format Patent
LanguageEnglish
French
Published 22.01.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

Abstract A class of macrocyclic compounds of formula (I), wherein R7,A,Ar, B,D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Alsoprovided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. L'invention porte sur une classe de composés macrocycliques représentés par la formule (I), dans laquelle R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y et Z sont tels que définis présentement, qui sont utiles comme inhibiteurs de protéases virales, en particulier la protéase NS3 du virus de l'hépatite C (VHC). L'invention porte également sur des procédés pour la synthèse et l'utilisation de tels composés macrocycliques pour le traitement ou la prévention de l'infection par le VHC.
AbstractList A class of macrocyclic compounds of formula (I), wherein R7,A,Ar, B,D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Alsoprovided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. L'invention porte sur une classe de composés macrocycliques représentés par la formule (I), dans laquelle R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y et Z sont tels que définis présentement, qui sont utiles comme inhibiteurs de protéases virales, en particulier la protéase NS3 du virus de l'hépatite C (VHC). L'invention porte également sur des procédés pour la synthèse et l'utilisation de tels composés macrocycliques pour le traitement ou la prévention de l'infection par le VHC.
Author STANSFIELD, IAN
NARJES, FRANK
MACKAY, ANGELA CLAIRE
RICO FERREIRA, MARIA DEL ROSARIO
HABERMANN, JOERG
CONTE, IMMACOLATA
Author_xml – fullname: MACKAY, ANGELA CLAIRE
– fullname: STANSFIELD, IAN
– fullname: RICO FERREIRA, MARIA DEL ROSARIO
– fullname: CONTE, IMMACOLATA
– fullname: HABERMANN, JOERG
– fullname: NARJES, FRANK
BookMark eNrjYmDJy89L5WTw8nV0DvJ3jnT28XRW8PRz8fdxVXBxDfIMcwzxDHMNVnDzD1II8XBVCAlydQzxdfULUfB3U_BwDQBKh3gGK4D0uLk6h3j6-wXzMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jAwNLA0MDcwtTR0Nj4lQBAEa_MBo
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
DocumentTitleAlternate DÉRIVÉS MACROCYCLIQUES D'INDOLE POUR LE TRAITEMENT DES INFECTIONS D'HÉPATITE C
ExternalDocumentID WO2009010785A1
GroupedDBID EVB
ID FETCH-epo_espacenet_WO2009010785A13
IEDL.DBID EVB
IngestDate Fri Jul 19 12:50:06 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
French
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_WO2009010785A13
Notes Application Number: WO2008GB50555
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090122&DB=EPODOC&CC=WO&NR=2009010785A1
ParticipantIDs epo_espacenet_WO2009010785A1
PublicationCentury 2000
PublicationDate 20090122
PublicationDateYYYYMMDD 2009-01-22
PublicationDate_xml – month: 01
  year: 2009
  text: 20090122
  day: 22
PublicationDecade 2000
PublicationYear 2009
RelatedCompanies STANSFIELD, IAN
NARJES, FRANK
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
MACKAY, ANGELA CLAIRE
RICO FERREIRA, MARIA DEL ROSARIO
HABERMANN, JOERG
CONTE, IMMACOLATA
RelatedCompanies_xml – name: CONTE, IMMACOLATA
– name: MACKAY, ANGELA CLAIRE
– name: STANSFIELD, IAN
– name: RICO FERREIRA, MARIA DEL ROSARIO
– name: HABERMANN, JOERG
– name: ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
– name: NARJES, FRANK
Score 2.7250335
Snippet A class of macrocyclic compounds of formula (I), wherein R7,A,Ar, B,D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090122&DB=EPODOC&locale=&CC=WO&NR=2009010785A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3PT8IwFH4haNSbokYUTRPNbosyBhsHYkbXZSOMEaiIJ7KVLjExg8iM_75vdSgnbk1f-tI2ef369f0owIONICRly9LbpiV0xONUTzpFgE2axKadGmaqflEIRx3_xRzM2_MKfGxzYVSd0G9VHBEtSqC95-q8Xv8_YrkqtnLzmLxj1-rZ4z1X27LjbuEp0tx-j40jN6IapcjbtNGklCEeth3kSgd4kbYKe2CzfpGXst4FFe8UDseoL8vPoCKzGhzT7d9rNTgKS5c3Nkvr25zDIHToJKJvdBhQEozcaMiIi0Rs5vBgxqYECR3hPiN8whxeFOknkUd8NkYxD6akGOMxFTQyvYB7j3Hq6zipxd8eLF6j3RW0LqGarTJ5BSQWRrxMra4lm6lpCitpJiI2bIlXNbF8EnYdGvs0Xe8X38DJr_ukqRtGA6r555e8RRTOkzu1eT99OIRs
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bT8IwFD4haMQ3RY0X1CaavS3KGGw8EDO6LhvuQqAiPpGtdImJGURm_PueTVCeeGt60pO2yenXr-dSgHsTQUjKlqG2dUOoiMepmnSKAJs0iXUz1fS0_EUhCDvuiz6YtqcV-NjkwpR1Qr_L4ohoUQLtPS_P6-X_I5ZdxlauHpJ37Fo8ObxnKxt23C08RYrd77FhZEdUoRR5mxKO1jLEw7aFXGkPL9lGYQ9s0i_yUpbboOIcwf4Q9WX5MVRkVoca3fy9VoeDYO3yxuba-lYnMAgsOoroG_U9SrzQjnxGbCRiE4t7EzYmSOgIdxnhI2bxokg_iRzisiGKuTcmxRiHlUEj41O4cxinroqTmv3twew12l5B6wyq2SKT50BiocXz1OgaspnqujCSZiJizZR4VRPzR2FeQGOXpsvd4luouTzwZ74XPl_B4a8rpalqWgOq-eeXvEZEzpObciN_AN9Vh18
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=MACROCYCLIC+INDOLE+DERIVATIVES+FOR+THE+TREATMENT+OF+HEPATITIS+C+INFECTIONS&rft.inventor=MACKAY%2C+ANGELA+CLAIRE&rft.inventor=STANSFIELD%2C+IAN&rft.inventor=RICO+FERREIRA%2C+MARIA+DEL+ROSARIO&rft.inventor=CONTE%2C+IMMACOLATA&rft.inventor=HABERMANN%2C+JOERG&rft.inventor=NARJES%2C+FRANK&rft.date=2009-01-22&rft.externalDBID=A1&rft.externalDocID=WO2009010785A1