MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS

A class of macrocyclic compounds of formula (I), wherein R7,A,Ar, B,D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Alsoprovided are processes for the synthesis and use of such m...

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Main Authors MACKAY, ANGELA CLAIRE, STANSFIELD, IAN, RICO FERREIRA, MARIA DEL ROSARIO, CONTE, IMMACOLATA, HABERMANN, JOERG, NARJES, FRANK
Format Patent
LanguageEnglish
French
Published 22.01.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A class of macrocyclic compounds of formula (I), wherein R7,A,Ar, B,D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Alsoprovided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. L'invention porte sur une classe de composés macrocycliques représentés par la formule (I), dans laquelle R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y et Z sont tels que définis présentement, qui sont utiles comme inhibiteurs de protéases virales, en particulier la protéase NS3 du virus de l'hépatite C (VHC). L'invention porte également sur des procédés pour la synthèse et l'utilisation de tels composés macrocycliques pour le traitement ou la prévention de l'infection par le VHC.
Bibliography:Application Number: WO2008GB50555