NOVEL FACULTATIVE CATONIC STEROLS

A facultative cationic sterol derivate, said sterol derivate has a pka value of between 3.5 and 8 and the general formula Cation-Spacer 2-Y-Spacer 1-X-Sterol wherein X and Y are linking groups and wherein at least on of X and Y is -NH(C=O)-O- and/or -0-(C=O)-NH. Also disclosed are liposomes comprisi...

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Bibliographic Details
Main Authors ENDERT, GEROLD, PANZNER, CORNELIA
Format Patent
LanguageEnglish
French
Published 24.12.2008
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:A facultative cationic sterol derivate, said sterol derivate has a pka value of between 3.5 and 8 and the general formula Cation-Spacer 2-Y-Spacer 1-X-Sterol wherein X and Y are linking groups and wherein at least on of X and Y is -NH(C=O)-O- and/or -0-(C=O)-NH. Also disclosed are liposomes comprising said sterol derivatives. L'invention porte sur un dérivé de stérol facultativement cationique présentant une valeur de pKa entre 3,5 et 8 et la formule générale Cation-Espaceur 2-Y-Espaceur 1-X-Stérol où X et Y sont des groupes de liaison et où au moins l'un parmi X et Y représente -NH(C=O)-O- et/ou -O-(C=O)-NH. L'invention porte également sur des liposomes comprenant lesdits dérivés de stérol.
Bibliography:Application Number: WO2008EP05221