DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS

The invention is directed to compounds having the formula: (I) wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also direc...

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Main Authors HUDSON, RYAN, CHOI, SEOK-KI, GENDRON, ROLAND, MCMURTRIE, DARREN, FATHEREE, PAUL, R, MCKINNELL, ROBERT, MURRAY, JENDZA, KEITH, ALLEGRETTI, PAUL, OLSON, BROOKE
Format Patent
LanguageEnglish
French
Published 18.12.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention is directed to compounds having the formula: (I) wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds. L'invention concerne des composés ayant la formule: (I) où Ar, r, n, X, R2-3 et R5-7 sont tels que définis dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. Ces composés ont une activité d'antagoniste de récepteurs AT1 et une activité d'inhibition de néprilysine. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés; des procédés d'utilisation de tels composés; et un procédé et des intermédiaires pour préparer de tels composés.
Bibliography:Application Number: WO2008US06976