NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS

The present invention provides a novel amide derivative and a pharmaceutically acceptable salt thereof which selectively and effectively inhibits the growth of cancer cells induced by the overexpression of an epidermal growth factor receptor and also prevents the development of drug resistance cause...

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Main Authors KO, MI YOUNG, KIM, MAENG SUP, CHA, MI YOUNG, PARK, BUM WOO, KIM, MI RA, LEE, CHANG GON, AHN, YOUNG-GIL, KIM, SE YOUNG, CHAE, YUN JUNG, CHOI, BO IM, BANG, KEUKCHAN, JUNG, YOUNG HEE, KIM, HAN KYONG, LEE, GWAN SUN, LEE, KWANG-OK
Format Patent
LanguageEnglish
French
Published 11.12.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a novel amide derivative and a pharmaceutically acceptable salt thereof which selectively and effectively inhibits the growth of cancer cells induced by the overexpression of an epidermal growth factor receptor and also prevents the development of drug resistance caused by the mutation of EGFR tyrosine kinase, and a pharmaceutical composition comprising same as an active ingredient. La présente invention concerne un nouveau dérivé d'amide, et son sel pharmaceutiquement acceptable, qui peut inhiber sélectivement et efficacement la croissance de cellules cancéreuses induites par la surexpression d'un récepteur du facteur de croissance épidermique, mais aussi empêcher le développement de la résistance au médicament causée par la mutation de la tyrosine kinase EGFR. L'invention concerne également une composition pharmaceutique comprenant ce dérivé coomme principe actif.
Bibliography:Application Number: WO2008KR03162