IMPROVED SYNTHESIS OF (2S-CIS)-2-(BROMOMETHYL)-2-(4-CHLOROPHENYL)-1,3 DIOXOLANE-4-METHANOL METHANESULFONATE(ESTER)

The present invention relates to an improved process for the preparation of (2S-cis)-2- (bromomethyl)-2-(4-chlorophenyl )-1,3-dioxolane-4-methanol methanesulfonate(ester), a key intermediate for the preparation of the apoB secretion/MTP inhibitor mitratapide. La présente invention porte sur un procé...

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Bibliographic Details
Main Authors FILLIERS, WALTER FERDINAND MARIA, BELLINKX, RONNY, VERSTAPPEN, WALTER LOUIS ANTOINE
Format Patent
LanguageEnglish
French
Published 04.12.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to an improved process for the preparation of (2S-cis)-2- (bromomethyl)-2-(4-chlorophenyl )-1,3-dioxolane-4-methanol methanesulfonate(ester), a key intermediate for the preparation of the apoB secretion/MTP inhibitor mitratapide. La présente invention porte sur un procédé perfectionné pour la préparation de méthanesulfonate de (2S-cis)-2-(bromométhyl)-2-(4-chlorophényl)-1,3 dioxolane-4-méthanol(ester), un intermédiaire clé pour la préparation du mitratapide inhibiteur de la sécrétion de apoB/de MTP.
Bibliography:Application Number: WO2008EP56355