EX VIVO METHODS FOR VALIDATING SUBSTANCE TESTING WITH HUMAN ORGANS AND/OR TISSUES

• Main Authors: KRAVITZ, DAVID, CURTIS, CHRISTOPHER GERALD, BRASSIL, JOHN
• Format: Patent
• Language: English; French
• Published: 19.03.2009
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HUMAN NECESSITIES; HUNTING; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PEST REPELLANTS OR ATTRACTANTS; PHYSICS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TESTING; TRAPPING

Methods of validating results of assessments of test substances using human derived tissues and/or organs, particularly tissues and/or organs unsuitable for transplantation, include assessing the suitability of the organ and/or tissue for substance testing, as well as inter-organ variability and use of exogenous and/or endogenous controls. La présente invention concerne des procédés de validation des résultats des évaluations de substances tests en utilisant des organes et/ou des tissus dérivés d'humains, en particulier des organes et/ou des tissus humains qui ne conviennent pas pour une transplantation. Les procédés incluent l'évaluation de l'applicabilité de l'organe et/ou du tissu au test des substances, ainsi que de la variabilité inter-organes et de l'utilisation de témoins exogènes et/ou endogènes.