PHARMACEUTICAL COMPOSITIONS FOR POORLY SOLUBLE DRUGS

The invention relates to solid dispersions of poorly soluble compounds formed by co-precipitation and hot melt extrusion, resulting in improved stability and bioavailability. The invention also relates to hot melt extrusion processes used to prepare such solid dispersions. L'invention porte sur...

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Bibliographic Details
Main Authors SHAH, NAVNIT HARGOVINDAS, SANDHU, HARPREET K, CHATTERJI, ASHISH, DONG, ZEDONG
Format Patent
LanguageEnglish
French
Published 07.01.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to solid dispersions of poorly soluble compounds formed by co-precipitation and hot melt extrusion, resulting in improved stability and bioavailability. The invention also relates to hot melt extrusion processes used to prepare such solid dispersions. L'invention porte sur des dispersions solides de composés solubles de façon médiocre, formées par coprécipitation et extrusion à chaud, conduisant à une stabilité et une biodisponibilité accrues. L'invention porte également sur des procédés d'extrusion à chaud utilisés pour préparer des telles dispersions solides.
Bibliography:Application Number: WO2008EP55292