CRYSTAL FORMS OF SAXAGLIPTIN AND PROCESSES FOR PREPARING SAME
Physical crystal structures of a compound of the formula (I): are provided including the free base monohydrate thereof (form H-1) and the hydrochloric acid salt thereof, including hydrochloric acid salt containing 0.75 equivalent of H2O (form H0.75-3) and hydrochloric acid salt containing 2 equivale...
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Main Authors | , , , , , , , , |
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Format | Patent |
Language | English French |
Published |
25.06.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Physical crystal structures of a compound of the formula (I): are provided including the free base monohydrate thereof (form H-1) and the hydrochloric acid salt thereof, including hydrochloric acid salt containing 0.75 equivalent of H2O (form H0.75-3) and hydrochloric acid salt containing 2 equivalents of H2O (form H2-1), and hydrochloric acid salt Pattern P-5, preferably in substantially pure form, and other forms as described herein, pharmaceutical compositions containing structures of compound I or IA, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
Cette invention a trait à des structures cristallines d'un composé de formule (I) comprenant sa base libre monohydratée (forme H-1) et son sel d'acide chlorhydrique, y compris le sel d'acide chlorhydrique contenant 0,75 équivalent de H2O (forme H0.75-3) et le sel d'acide chlorhydrique contenant 2 équivalents de H2O (forme H2-1), et le sel d'acide chlorhydrique motif P-5, de préférence sous forme sensiblement pure, et d'autres formes telles que décrites dans l'invention; l'invention concerne également des compositions pharmaceutiques contenant des structures du composé I ou IA, des procédés de préparation associés, des intermédiaires utilisés dans leur préparation, et des procédés de traitement des maladies comme le diabète utilisant ces structures. |
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Bibliography: | Application Number: WO2008US60711 |