PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS

• Main Authors: BEBERNITZ, GREGORY, RAYMOND, KIRMAN, LOUISE, BAJWA, JOGINDER, S, CHEN, GUANG-PEI, LEE, GEORGE, TIEN-SAN, KAPA, PRASAD, KOTESWARA, SCHUSTER, HERBERT, FRANZ, SCLAFANI, JOSEPH, JIANG, XINGLONG
• Format: Patent
• Language: English; French
• Published: 09.10.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to a process for the preparation of a (R)-3-Cycloalkyl-2-[4-(4-substitued amine-1-sulfonyl)-phenyl]-N-(5-substituent-yl-thiazolo[5,4-b]pyridin-2-yl)-propionamide comprising: (a) taking a chiral compound a formula 6 and forming an acid chloride in situ; (b) reacting the...