10H-BENZO(G)PTERDINE-2,4-DIONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
This invention pertains generally to the field of G-quadruplex ligands, and more particularly, to certain 10H-benzo[g]pteridine-2,4-dione compounds ("BPD compounds"), as described herein, which, inter alia, (selectively) bind (and stabilize) G-quadruplexes. The present invention also perta...
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Main Authors | , |
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Format | Patent |
Language | English French |
Published |
25.09.2008
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Subjects | |
Online Access | Get full text |
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Summary: | This invention pertains generally to the field of G-quadruplex ligands, and more particularly, to certain 10H-benzo[g]pteridine-2,4-dione compounds ("BPD compounds"), as described herein, which, inter alia, (selectively) bind (and stabilize) G-quadruplexes. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) bind (and stabilize) G-quadruplexes, to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative disorders, such as cancer. Formula (I):
L'invention concerne de manière générale le domaine des ligands G-quadruplex, et plus particulièrement certains composés 10H-benzo[g]ptéridine-2,4-dione (composés BPD), tels que décrits dans le présent document, qui se lient (sélectivement) à (et stabilisent) les G-quadruplex, entre autres. La présente invention concerne également des compositions pharmaceutiques qui comprennent de tels composés et l'utilisation de tels composés et de telles compositions, à la fois in vivo et in vitro, pour se lier (sélectivement) à (et stabiliser) les G-quadruplex, pour inhibiter la télomérase, pour réguler la prolifération cellulaire et pour le traitement de troubles prolifératifs, tels que le cancer. |
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Bibliography: | Application Number: WO2008GB00962 |