METHODS OF TREATING CANCER BY INTERFERING WITH IGF-I RECEPTOR SIGNALING

• Main Authors: GHOSH, PAPIA, KIM, YONGSOON, SUN, HONG
• Format: Patent
• Language: English; French
• Published: 18.09.2008
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMES; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

The invention includes methods of reducing proliferation, causing apoptosis and treating cancer through the inhibition of ASM, the disruption of lipid rafts and the interference with IGF-IR and Racl signaling using a variety of compounds including siRNA, anti-ASM antibodies, anti-ceramide antibodies, short- chain ceramide derivatives, desipramine, clomipramine, mangostin and/or sphingomyelin substrate analogues. L'invention concerne des procédés pour réduire la prolifération, provoquer l'apoptose et traiter le cancer grâce à l'inhibition d'ASM, la rupture de radeaux lipidiques et l'interférence avec une signalisation d'IGF-IR et de Racl en utilisant une pluralité de composés comprenant de l'ARNsi, des anticorps anti-ASM, des anticorps anticéramide, des produits dérivés de céramide à courte chaîne, des analogues de substrat de désipramine, clomipramine, mangostine et/ou sphingomyéline.