QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS

The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings. La présente invention porte sur des composés de Formule (I), sur leur utilisat...

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Main Authors FREYNE, EDDY JEAN EDGARD, VIALARD, JORGE EDUARDO, PILATTE, ISABELLE NOELLE CONSTANCE, PONCELET, VIRGINIE SOPHIE, ROUX, BRUNO, MEYER, CHRISTOPHE, MEVELLEC, LAURENCE ANNE, ADELINET, CHRISTOPHE DENIS, MARCONNET-DECRANE, LAURENCE FRANCOISE BERNADETTE, BOURDREZ, XAVIER MARC, MACRITCHIE, JACQUELINE ANNE, OWENS, ANDREW PATE, STORCK, PIERRE-HENRI, DUFFY, JAMES EDWARD STEWART, ANGIBAUD, PATRICK RENE, PASQUIER, ELISABETH THERESE JEANNE
Format Patent
LanguageEnglish
French
Published 12.09.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings. La présente invention porte sur des composés de Formule (I), sur leur utilisation comme inhibiteurs de PARP ainsi que sur des compositions pharmaceutiques comprenant lesdits composés, où R1, R2, R3, R4, R5, R6, R7, n, m et X ont les significations définies.
Bibliography:Application Number: WO2008EP52764