BONE/CARTILAGE FORMATION-STIMULATING AGENT

• Main Authors: MIYAZAKI, TATSUYA, MIYAUCHI, SATOSHI, MATSUZAKA, SATOSHI, SUZUKI, OSAMU
• Format: Patent
• Language: English; French; Japanese
• Published: 28.08.2008
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

Disclosed is a mixture of: a bone/cartilage formation-stimulating agent comprising sulfated galactosaminoglycan having 0.6 or more sulfate ester group(s) on average per one constituent monosaccharide or a salt thereof as an active ingredient; and a factor having a bone/cartilage formation-stimulating activity or a bone defect filler (BMP, TGF-ß, FGF, IGF, insulin, PDGF, HGF, midkine, pleiotrophin, collagen, gelatin, proteoglycan, fibronectin, osteocalcin, osteopontin, osteonectin, bone sialoprotein, hydroxyapatite, dicalcium phosphate anhydride, dicalcium phosphate dihydrate, a-tricalcium phosphate, amorphous calcium phosphate, octacalcium phosphate, ß-tricalcium phosphate, PLLA, PLGA, titanium, decalcified bone, autogenous bone, etc.). L'invention porte sur un mélange de : un agent de stimulation de la formation d'os/cartilage comprenant un galactosaminoglycane sulfaté ayant en moyenne 0,6 groupe ester sulfate ou plus par monosaccharide constitutif ou un sel de celui-ci comme ingrédient actif ; et un facteur ayant une activité de stimulation de la formation d'os/cartilage ou un remplissage de défaut osseux (BMP, TGF-ß, FGF, IGF, insuline, PDGF, HGF, midkine, pléiotrophine, collagène, gélatine, protéoglycane, fibronectine, ostéocalcine, ostéopontine, ostéonectine, sialoprotéine d'os, hydroxyapatite, anhydride de phosphate dicalcique, dihydrate de phosphate dicalcique, phosphate a-tricalcique, phosphate de calcium amorphe, phosphate octacalcique, phosphate ß-tricalcique, PLLA, PLGA, titanium, os décalcifié, os autogène, etc.).