PROTEIN FORMULATIONS CONTAINING SORBITOL

The present invention provides a method for suppressing protein aggregation in a liquid formulation during freeze-thaw by including sorbitol in the liquid formulation. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and sorbitol such th...

Full description

Saved in:
Bibliographic Details
Main Author SEK, DAVID, C
Format Patent
LanguageEnglish
French
Published 21.08.2008
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention provides a method for suppressing protein aggregation in a liquid formulation during freeze-thaw by including sorbitol in the liquid formulation. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and sorbitol such that the presence of sorbitol suppresses protein aggregation during freezing and/or thawing. L'invention concerne un procédé pour supprimer l'agrégation de protéines dans une formulation liquide pendant une congélation-décongélation en incluant du sorbitol dans la formulation liquide. La présente invention concerne également des procédés pour stocker et préparer une formulation liquide contenant une protéine et du sorbitol, de telle sorte que la présence de sorbitol supprime l'agrégation de protéines pendant la congélation et/ou la décongélation.
Bibliography:Application Number: WO2008US54110