NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT

The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically accepatble salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral...

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Bibliographic Details
Main Authors PERRY, JASON, K, CHEN, JAMES, M, MACKMAN, RICHARD, L, SAUNDERS, OLIVER, L, HUANG, ALAN, X, PARRISH, JAY, P, SPERANDIO, DAVID
Format Patent
LanguageEnglish
French
Published 24.12.2008
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically accepatble salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans). La présente invention concerne des phosphonates insaturés de formule (I) ou un tautomère ou un sel pharmaceutiquement acceptable de ceux-ci, ainsi que des compositions pharmaceutiques comportant les composés, et des procédés thérapeutiques comprenant l'administration des composés. Les composés présente des propriétés antivirales et sont utiles pour traiter des infections (par exemple, le VHC) chez des animaux (par exemple, des humains).
Bibliography:Application Number: WO2008US01743