TREATMENT OF AORTIC DISSECTION OR ANEURYSM

• Main Authors: RAGHEB, ANTHONY, O, RUANE, PATRICK, H, GREWE, DAVID, D, BIGGS, DAVID, PAUL
• Format: Patent
• Language: English; French
• Published: 31.07.2008
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

This application relates to methods for treating an aneurysm or an aortic dissection (230; 530). The methods include delivering a medical device (10; 100; 150; 200; 400) and a c-Jun N-terminal kinase (JNK) inhibitor compound to a body lumen at a point of treatment within a subject having the aneurysm or aortic dissection (230; 530), the medical device (10; 100; 150; 200; 400) being adapted to release the JNK inhibitor within the body lumen of the subject. This application also relates to medical devices (10; 100; 150; 200; 400) and JNK inhibitor compounds, where the medical device (10; 100; 150; 200; 400) is adapted to release the JNK inhibitor compound within a patient. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters. L'invention porte sur des méthodes de traitement d'anévrismes ou d'anévrismes disséquants (230; 530) consistant à introduire dans un dispositif médical (10; 100; 150; 200; 400) et un composé inhibiteur de la c-june N-terminal kinase (JNK) dans une lumière corporelle sur le site de traitement d'un patient souffrant d'un anévrisme ou d'un anévrisme disséquant (230; 530), le dispositif médical (10; 100; 150; 200; 400) étant conçu pour libérer l'inhibiteur JNK dans la lumière corporelle du patient. L'invention porte également sur des dispositifs médicaux (10; 100; 150; 200; 400) et des composés d'inhibiteur JNK, lesdits dispositifs médicaux (10; 100; 150; 200; 400) étant conçus pour libérer le composé d'inhibiteur JNK dans un patient. Ces dispositifs médicaux peuvent inclure: des stents recouverts, des greffes stents, des ballonnets et des cathéters.