DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES

The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-l a and human IL-I ß. The dual specific antibodies of the invention also neutralize both human IL-I a and human IC-I ß. The invention also provides domain antibodies (dAb...

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Main Authors HSIEH, CHUNG-MING, TOMLINSON, IAN, ENEVER, CARRIE, MCRAE, BRADFORD, L, KUTSKOVA, YULIYA, TUNA, MIHRIBAN, MEMMOTT, JOHN, E, GRANT, STEVEN, ROGUSKA, MICHAEL
Format Patent
LanguageEnglish
French
Published 10.07.2008
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-l a and human IL-I ß. The dual specific antibodies of the invention also neutralize both human IL-I a and human IC-I ß. The invention also provides domain antibodies (dAbs) specific for human IL-l a and human IL-l ß. L'invention concerne un anticorps à double spécificité isolé, ou une partie de liaison à un antigène de celui-ci, qui est spécifique à IL-l a et à IL-I ß humains. Les anticorps à double spécificité selon l'invention neutralisent également aussi bien IL-I a humain que l'IC-I ß humain. L'invention concerne enfin des anticorps à domaine (dAbs) spécifiques à IL-l a et à IL-l ß humains.
Bibliography:Application Number: WO2007US26482