PLANT DERIVED ANTIBIOTIC PEPTIDE RICH IN GLYCINE

The present invention relates to a novel peptide extracted from guava (Psidium guajava) seeds, that provides bactericide activity, preferentially against Gram-negative bacteria which are known to cause urinary, hospital, and intestinal tract infections (Proteus sp. and Klebsiella sp.). The peptide,...

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Main Authors JUNIOR, CARLOS BLOCH, PELEGRINI, PATRICIA BARBOSA, SILVA, LUCIANO PAULINO DA, FRANCO, OCTAVIO LUIZ
Format Patent
LanguageEnglish
French
Published 10.07.2008
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to a novel peptide extracted from guava (Psidium guajava) seeds, that provides bactericide activity, preferentially against Gram-negative bacteria which are known to cause urinary, hospital, and intestinal tract infections (Proteus sp. and Klebsiella sp.). The peptide, that has the amino acid sequence RESPSSRMEC YEQAERYGYG GYGGGRYGGG YGSGRGQPVG QGVERSHDDN RNQPR, belongs to the class of glycine rich proteins and has approximately 5 kDa of molecular weight. The invention also relates to antibiotic compositions for human, veterinary and plant treatments. Alternatively, the peptide, or a functionally similar derivative, subjects of the present invention, can be used for transforming organisms aiming pathogen resistance, other adaptive advantages, as well as various properties, specially for plants and animals. L'invention porte sur un nouveau peptide extrait des graines de goyave (Psidium guajava), qui présentent une activité bactéricide, de préférence contre les bactéries Gram-négatives connues pour causer des infections urinaire, nosocomiales et du tube digestif (Proteus sp. et Klebsiella sp.). Ledit peptide, qui présente la séquence d'acides aminés RESPSSRMEC YEQAERYGYG GYGGGRYGGG YGSGRGQPVG QGVERSHDDN RNQPR, appartient à la classe des protéines riches en glycine et a un poids moléculaire d'environ 5 kDa. L'invention porte également sur des compositions antibiotiques de traitement de l'homme des animaux et des plantes. Par ailleurs, ledit peptide, ou l'un de ses dérivés à fonction similaire, qui peuvent servir à transformer des organismes pour leur octroyer une résistance aux pathogènes, ont d'autres avantages adaptatifs, ainsi que diverses propriétés, particulièrement pour le traitement des plantes et des animaux.
Bibliography:Application Number: WO2008BR00001