QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions. Cette invention concerne de nouveaux composés qui sont des i...

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Main Authors RAMURTHY, SAVITHRI, WARNE, ROBERT, L, ZHOU, YASHEEN, LIN, XIAODONG, SUBRAMANIAN, SHARADA, MURRAY, JEREMY, M, BASHAM, STEVEN, E, WANG, XIAOJING, M, RICO, ALICE, C, DOVE, JEFFREY, AIKAWA, MINA, AMIRI, PAYMAN, JAIN, RAMA, SHU, WEI
Format Patent
LanguageEnglish
French
Published 12.05.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions. Cette invention concerne de nouveaux composés qui sont des inhibiteurs de PDK1. Elle concerne également des compositions pharmaceutiques contenant ces composés, et des méthodes utilisant ces composés et compositions pour le traitement de maladies à évolution chronique comme le cancer.
Bibliography:Application Number: WO2007US88392