HETEROBICYCLIC METALLOPROTEASE INHIBITORS

• Main Authors: NOLTE, BERT, STEENECK, CHRISTOPH, GALLAGHER, JR., BRIAN M, GEGE, CHRISTIAN, SUCHOLEIKI, IRVING, CHEVRIER, CARINE, WU, XINYUAN, HOCHGUERTEL, MATTHIAS, DENG, HONGBO, SCHNEIDER, MATTHIAS, BOSIES, MICHAEL, TAVERAS, ARTHUR
• Format: Patent
• Language: English; French
• Published: 29.05.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit...