HETEROBICYCLIC METALLOPROTEASE INHIBITORS

• Main Authors: NOLTE, BERT, STEENECK, CHRISTOPH, GALLAGHER, JR., BRIAN M, GEGE, CHRISTIAN, SUCHOLEIKI, IRVING, CHEVRIER, CARINE, WU, XINYUAN, HOCHGUERTEL, MATTHIAS, DENG, HONGBO, SCHNEIDER, MATTHIAS, BOSIES, MICHAEL, TAVERAS, ARTHUR
• Format: Patent
• Language: English; French
• Published: 29.05.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors. L'invention concerne, de manière générale, des agents pharmaceutiques contenant de l'azabicyclique, et notamment des composés inhibant la métalloprotéase azabicyclique. Cette invention concerne plus particulièrement une nouvelle classe de composés inhibant les MMP-3, MMP-8 et/ou MMP-13 azabicycliques, qui offre une puissance et une sélectivité améliorées par rapport aux inhibiteurs de MMP-13, MMP-8 et MMP-3 actuellement connus.