AN IMPROVED PROCESS FOR THE PREPARATION OF RIMONABANT

The present invention relates to an industrially advantageous, eco-friendly process for the re aration of rimonabant of formula-(I), staring from l-(4-chlorophenyl)-propan-l-one in high yields and high purity by using mild reaction conditions and avoiding use of toxic and expensive reagents, as well...

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Main Authors WADHWA, LALIT, SARIN, GURDEEP, SINGH, AGGARWAL, ASHVIN, KUMAR, SRINIVASAN, CHIDAMBARAM, VENKATESWARAN
Format Patent
LanguageEnglish
French
Published 29.05.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to an industrially advantageous, eco-friendly process for the re aration of rimonabant of formula-(I), staring from l-(4-chlorophenyl)-propan-l-one in high yields and high purity by using mild reaction conditions and avoiding use of toxic and expensive reagents, as well as stringent reaction conditions. The present invention relates to an isolated impurity of rimonabant, referred to as "Bis impurity" and removal thereof.1 The present invention also relates to novel crystalline form-Ill of rimonabant and processes for its preparation and conversion to form-I of rimonabant. L'invention porte sur un procédé industriellement avantageux, écologique et à fort rendement, de préparation de rimonabant de formule (I) de grande pureté, à partir de l-(4-chlorophényle)-propane-l-one en utilisant des conditions de réaction douces et en évitant l'utilisation de réactifs toxiques et chers, aussi bien que des conditions de réaction contraignantes. L'invention porte également sur l'isolement et l'élimination d'une impureté du rimonabant, dite "impureté Bis ". L'invention porte en outre sur une nouvelle forme cristalline de formule (III) du rimonabant et sur son procédé de préparation et de conversion pour obtenir le rimonabant de formule (I)
Bibliography:Application Number: WO2007IN00546